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#1 Nov 16, 2020 8:22 am

Slice
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EXPAT YOU TAKE ON ANOTHER MORE EFFECTIVE VACCINE

https://www.washingtonpost.com/health/2 … a-vaccine/

Biotechnology firm Moderna announced Monday that a preliminary analysis shows its experimental coronavirus vaccine is nearly 95 percent effective at preventing illness, including severe cases — a striking initial result that leaves the United States with the prospect that two coronavirus vaccines could be available on a limited basis by the end of the year.

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The news comes a week after pharmaceutical giant Pfizer and its German partner BioNTech lifted the stock market and people’s hopes with the news that their coronavirus vaccine was more than 90 percent effective.

“It’s extremely good news. If you look at the data, the numbers speak for themselves,” said Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases, who was one of three people briefed on the data by an independent committee Sunday morning. “I describe myself as a realist, but I’m fundamentally a cautious optimist. I felt we’d likely get something less than this. … I said certainly a 90-plus-percent effective vaccine is possible, but I wasn’t counting on it.”

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Moderna’s vaccine, co-developed with Fauci’s institute, is being tested in 30,000 people. Half received two doses of the vaccine, and half received a placebo. To test how well the vaccine works, physicians closely monitored cases of covid-19 to see whether they predominantly occurred in people who received the placebo group.

Of the 95 cases of covid-19, the disease caused by the virus, 90 were in the group that received the placebo. There were 11 severe cases reported — all in people who received the placebo. With cases of covid-19 confined almost exclusively to trial participants receiving a placebo, that sends a strong signal that the vaccine is effective at thwarting the virus.

The data have not yet been published or peer reviewed, and the overall effectiveness of the vaccine may change as the study continues. But Fauci said the data on severe cases was “quite impressive” and effectively answers a question that has lingered: whether a vaccine measured by its success in preventing any case of covid-19 can prevent the most urgent cases, too.

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An independent data committee, convened by the National Institutes of Health, analyzed the results Sunday morning. Stéphane Bancel, chief executive of Moderna, said in an interview that he spent the morning trying to distract himself from wondering about the results by working at his home in Boston, but instead he found himself constantly checking his phone and email. When he learned the results later in the morning, the evidence that the vaccine prevented severe disease stood out as most consequential.

“In this pandemic, what has been awful from a public health standpoint, an economic standpoint, is the worry people have to get so sick they have to go to the hospital — so sick they have to get to the ICU and have a high risk of dying,” Bancel said. “If a [vaccine] could prevent 95 percent of people to not get disease, but to not get severe disease, that would be a game-changer: the impact on hospitals, the impact on people’s psyche and the impact on deaths.”

Moderna has committed to completing its trial before applying for emergency-use authorization — which means waiting until there are 151 cases of covid-19 in the study. A previous projection showed that the trial might end sometime early next year, but it is instead expected to reach its endpoint in seven to 10 days, Bancel said, because of surging coronavirus cases in the United States. The explosion of virus cases translates into an expedited ability to ascertain whether a vaccine works.

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#2 Nov 16, 2020 9:31 am

Expat
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Re: EXPAT YOU TAKE ON ANOTHER MORE EFFECTIVE VACCINE

>>Of the 95 cases of covid-19, the disease caused by the virus, 90 were in the group that received the placebo. There were 11 severe cases reported — all in people who received the placebo. With cases of covid-19 confined almost exclusively to trial participants receiving a placebo, that sends a strong signal that the vaccine is effective at thwarting the virus.<<

So 5 people who had the vaccine out of those that got the virus GOT THE VIRUS. Out of a 30,000 in the experiment. Do the Maths.  Jeees.

There are lots of cases of reactions, and apparently 11 severe cases. what ever that might mean.

At the moment it is all bullshit.  There is no challenge trial, it is happenstance that the 95 people got or didn't get the infection. with a disease/virus, what ever you want to call it, that only affects 10 to 20% of the people who come into contact with it.  What the F are they proving. It is Bullshite.... And just now you won't be able to go to school. you won't be able to fly, you will be a pariah if you don't get vaccinated.

Britain's Labour leader wants to make anti vax messages illegal. I am not saying some of the conspiracy theories are not total bullshite too, I totally accept there are nut cases out there, but this proposal would stop any genuine debate. It is an attempt at oppression of the people.

Whether RD wants to be a guinea pig is his personal choice, and I would make my comments, but I would not try stop his free choice to take risks I would not take if he wants to.  But by the same token I do not understand with his libertarian leaning how he could think Government dictating we are compelled to take an experimental drug is OK.

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#3 Nov 16, 2020 9:52 am

Real Distwalker
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Re: EXPAT YOU TAKE ON ANOTHER MORE EFFECTIVE VACCINE

I don't think anyone should be forced to have the vaccine.

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#4 Nov 16, 2020 2:28 pm

Real Distwalker
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Re: EXPAT YOU TAKE ON ANOTHER MORE EFFECTIVE VACCINE

Jerusalem Post wrote:

Of the 95 reaction cases in Moderna’s trial, 11 were severe and all 11 occurred among volunteers who got the placebo.

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#5 Nov 16, 2020 3:02 pm

houston
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Re: EXPAT YOU TAKE ON ANOTHER MORE EFFECTIVE VACCINE

Looks like we'll have some time decide on whether or not to get vaccinated.

https://financialpost.com/executive/pos … -year-away

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#6 Nov 16, 2020 6:10 pm

Expat
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Re: EXPAT YOU TAKE ON ANOTHER MORE EFFECTIVE VACCINE

Real Distwalker wrote:
Jerusalem Post wrote:

Of the 95 reaction cases in Moderna’s trial, 11 were severe and all 11 occurred among volunteers who got the placebo.

OK, clarification on specifics, but I am pretty sure there were a LOT of less serious cases. Initially before ICAn put its boot in via court cases they weren't even testing against a none active placebo, it was the new vaccine compared to a "pretty safe" vaccine.... so even then some people might have an adverse reaction to the placebo... they are tricky buggers.

Initially taking advil was an accepted part of the treatment... so it was a less adverse affect if you took ANOTHER drug.

We are all shooting off anecdotal points, but I did put the actual test PDF for the first part of the trial ... as recieved from the drug company.Just the tiny part I read did not make for comfortable reading.

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